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The Division of Renal Diseases
and Hypertension has an exceptional faculty with over 20 NIH funded
grants, placing the Division in the top ten in the country for research
funding.
Research projects are listed
below:
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| Polycystic
kidney disease (PKD)
mTOR
signaling in experimental
models of polycystic kidney disease (Charles Edelstein)
Epidemiology
and Genetics (Berenice Gitomer)
HALT
trial (Robert Schrier)
TEMPO
(Tolvaptan Efficacy and safety in Management of Polycystic kidney
disease and its Outcomes) Phase 2 and 3 (Charles Edelstein)
Clinical
trials in children with PKD (Melissa Cadnapornchai, Robert Schrier) |
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Acute
Kidney injury (AKI)
Pathogenesis
of septic AKI (Robert Schrier)
Pathogenesis
of ischemic and cisplatin-induced AKI (Charles Edelstein)
Complement
system in ischemic AKI (Joshua Thurman)
Systemic
manifestations of AKI (Sarah Faubel)
Organ
preservation and effects of hibernation on kidney function (Alkesh
Jani, Charles Edelstein)
Biomarkers
of acute kidney injury in cardiac and liver transplant patients
(Charles Edelstein)
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Chronic
kidney disease (CKD)
Chronic
Kidney Disease and Vitamin D metabolism (M Chonchol, D Spiegel)
Progression
of Kidney Disease (Tomas Berl and Michel Chonchol)
Cardiovascular
disease and mineral-bone disorders (Michel Chonchol)
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Renal
metabolism
Low
fructose diet to reduce metabolic syndrome (Diana Jalal)
Fructose
in kidney disease and metabolic syndrome (Taka Nakagawa, Chris
Rivard, Richard Johnson)
Lipids
and renal disease (Moshe Levi)
Reguation
of phosphate transport (Moshe Levi)
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Hypertension
Uric
acid in the pathogenesis of hypertension and kidney disease (Taka
Nakagawa, Richard Johnson)
Pathogenesis
of essential hypertension (Richard Johnson, Taka Nakagawa, Raphael
Nemenoff)
Models
of vascular injury (Seth Ferguson, Mary Weiser-Evans)
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Transplantation
Various
clinical trials in renal transplant patients (james Cooper Alexander
Wiseman and Larry Chan)
Biomarkers
of delayed graft function in pigs and humans (Alkesh Jani, Charles
Edelstein)
Biology
of transplant rejection (Wiseman)
Application
of NMR and other molecular biomarkers in allograft rejection (Larry
Chan)
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Glomerulonephritis
Minimal
change disease (Richard Johnson, Gabriela Garcia)
Experimental
models of glomerulonephritis (Richard Johnson, Gabriela Garcia)
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Diabetic
nephropathy
Animal
models of diabetic nephropathy (Moshe Levi)
Pathogenesis
and prevention of renal disease in diabetes, obesity, and aging
(Tao Jiang, Moshe Levi)
Diabetic
Nephropathy: pathogenesis and treatment (Taka Nakagawa, Richard
Johnson, Moshe Levi)
Risk
factors for hypertension, metabolic syndrome and diabetes (Diana
Jalal, Michel Chonchol)
Collaborative
study group (Tomas Berl)
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Basic
Membrane
trafficking in renal tubular cells (Judy Blaine)
Genetic
mouse models of disease (Raphael Nemenoff, Mary Weiser-Evans)
Cellular
and molecular biology of hormone signaling (Raphael Nemenoff,
Mary Weiser-Evans)
Vasopressin
and aquaporin biology (Robert Schrier, Tomas Berl )
Pathways
controlling progression and metastasis of cancer (Raphael Nemenoff)
Response
of vascular smooth muscle cells to injury (Raphael Nemenoff)
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| Medical
informatics (David Spiegel) |
| Microscopy
Core: Advanced
microscopy core that provides state of the art confocal microscopy
and intravital microscopy for the imaging of cellular and subcellular
structures (see Microscopy Core) |
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Renal
Clinical Trials Office
Various
pharmaceutical company and NIH-funded clinical trials
Janis
Cicerchi (Head), Andrea Singleton, Lois Clegg, Kathy Duncan, Ann
Cline, Eric Harvester
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